| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 20-02-25 17:45 | FK Bodö/Glimt | FC Twente Enschede | 5:2a.p. |
| 20-02-25 17:45 | FCSB Bukarest | PAOK Salónica | 2:0 |
| 20-02-25 17:45 | Galatasaray Istambul | AZ Alkmaar | 2:2 |
| 20-02-25 17:45 | AS Roma | FC Porto | 3:2 |
| 20-02-25 20:00 | RSC Anderlecht | Fenerbahce Istambul | 2:2 |
| 20-02-25 20:00 | Ajax Amsterdão | Royale Union Saint-Gilloise | 1:2a.p. |
| 20-02-25 20:00 | Real Sociedad | FC Midtjylland | 5:2 |
| 20-02-25 20:00 | Viktoria Plzeň | Ferencvaros Budapest | 3:0 |