| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 21-01-25 15:30 | Galatasaray Istambul | Dínamo Kiev | 3:3 |
| 22-01-25 15:30 | Besiktas Istambul | Athletic Bilbao | 4:1 |
| 23-01-25 17:45 | AZ Alkmaar | AS Roma | 1:0 |
| 23-01-25 17:45 | Malmö FF | FC Twente Enschede | 2:3 |
| 23-01-25 17:45 | FK Bodö/Glimt | Maccabi Tel Avive | 3:1 |
| 23-01-25 17:45 | Qarabag | FCSB Bukarest | 2:3 |
| 23-01-25 17:45 | Viktoria Plzeň | RSC Anderlecht | 2:0 |
| 23-01-25 17:45 | 1899 Hoffenheim | Tottenham Hotspurs | 2:3 |
| 23-01-25 17:45 | FC Porto | Olympiakos Pireu | 0:1 |
| 23-01-25 17:45 | Fenerbahce Istambul | Olympique Lyon | 0:0 |
| 23-01-25 20:00 | Rigas Futbola Skola | Ajax Amsterdão | 1:0 |
| 23-01-25 20:00 | PFC Ludogorets Razgrad | FC Midtjylland | 0:2 |
| 23-01-25 20:00 | Royale Union Saint-Gilloise | Sporting Braga | 2:1 |
| 23-01-25 20:00 | IF Elfsborg Boras | OGC Nice | 1:0 |
| 23-01-25 20:00 | Eintracht Frankfurt | Ferencvaros Budapest | 2:0 |
| 23-01-25 20:00 | Manchester United | Glasgow Rangers | 2:1 |
| 23-01-25 20:00 | Lazio Roma | Real Sociedad | 3:1 |
| 23-01-25 20:00 | PAOK Salónica | Slavia Praga | 2:0 |